Allergic Reactions to Gadolinium Chelates

Val M. Runge, M.D.
Editor-in-Chief, Investigative Radiology
Robert and Alma Moreton Centennial Chair in Radiology
Scott and White Clinic and Hospital
Texas A&M University Health Science Center Temple, Texas USA

“to date no prospective well-designed study has ever shown a significant difference in the reported adverse reaction rates among the available gadolinium chelates, either for nuisance reactions, such as headache or nausea, or for serious adverse events, such as anaphylaxis”

“the five gadolinium chelates currently on the U.S. market with extracellular distribution—in order of their FDA approval, Magnevist, ProHance, Omniscan (gadodiamide, GE Healthcare), OptiMARK, and MultiHance—cannot be differentiated on the basis of nausea, vomiting, or hives, the most common nuisance reactions”

1. Runge VM. Gadolinium and nephrogenic systemic fibrosis.
AJR Am J Roentgenol 2009;192(4):W195-196.

2. Runge VM. Allergic reactions to gadolinium chelates. AJR
Am J Roentgenol 2001;177(4):944-945.

Clinical MRI by Val M. Runge, MD